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KMID : 0878220080200020058
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Journal of Sasang Constitutional Medicine
2008 Volume.20 No. 2 p.58 ~ p.71
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Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, Daejeon Univ
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Lee Soo-Young
Ahn Taek-Won
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Abstract
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Objectives : The purpose of this study is to investigate the anti-aging effect of oral administration with Nocyongdaebo-tang (NYD) decoction in aged rats.
Methods : The SD rats used in this experiment were 6, 18 and 36 weeks old. A part of the 36weeks was grown to 52 and 68 weeks at labarotary. Each age group was again divided into three groups. These 15 groups consisted of 6 rats each. One group was given no treatment, another group was dosed 200 of normal saline daily, and the last group was dosed 200 of 1% Nocyongdaebo-tang(NYD) and saline mixture. At the conclusion of the experiment, the age groups were relabelled accordingly(10w, 22w, 40w, 52w and 68w). After 4 weeks, the tissue of liver, heart, spleen, lung, kidney and brain was biopsied in order to measure the SOD, GSH, MDA.
Results and Conclusions : (1) The levels of GSH in the liver were significantly increased in the w-NYD(n=40) and w-NYD(n=68) groups compared with those of the normal groups. The activity of catalase in the liver was also much higher in the w-NYD (n=68) group compared with that of the saline groups. However, the levels of MDA in the liver were significantly decreased in the w-NYD(n=68) group compared with those of the normal and saline groups. (2) The levels of GSH in the spleen were significantly increased in the w-NYD(n=52) and w-NYD(n=68) groups compared with those of the normal and saline groups. (3) The levels of GSH in the lung were significantly increased in the w-NYD(n=40) and w-NYD(n=52) groups compared with those of the normal groups. (4) The levels of GSH in the kidney were higher in the w-NYD(n=40) compared with those of the normal groups and those were also higher in the w-NYD(n=52) groups compared with those of the saline groups, respectively. (5) The levels of GSH in the brain were higher in the w-NYD(n=40) compared with those of the normal groups and those were also higher in the w-NYD(n=52) groups compared with those of the normal and saline groups. (6) Degenerative changes of the brain were decreased in the w-NYD(n=68) group compared with those of the normal and saline groups. These results suggest that oral administration of Nocyongdaebo-tang decoction might have an important role to prevent age-related changes of various organs in aged rats.
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KEYWORD
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Nocyongdaebo-tang, Anti-aging Effect, GSH, MDA
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